DRUGS INTERFERING IN DIFFERENT PATHOLOGICAL TESTS
Drugs can interfere with various pathological tests,
leading to inaccurate results. Here’s a brief overview of drugs and their
potential effects on different types of pathological tests:
1. Hematology Tests
- Anticoagulants
(e.g., Warfarin, Heparin): Prolong clotting time
in PT (Clotting Time).
- Corticosteroids:
Can increase white blood cell count.
- Chemotherapy
Drugs: May reduce red blood cell, white blood cell, and platelet counts.
2. Biochemistry Tests
- Diuretics
(e.g., Furosemide): May alter electrolytes like potassium and sodium.
- Statins:
Elevate liver enzymes (AST,
ALT).
- Metformin:
May increase lactate levels,
affecting tests for lactic acidosis.
- Paracetamol
(Overdose): Can increase liver enzyme levels.
3. Hormonal and Endocrine Tests
- Glucocorticoids:
Suppress adrenal hormones,
affecting cortisol levels.
- Thyroxine
or Antithyroid Drugs: Alter T3, T4 levels.
4. Urine Tests
- Vitamin
C Supplements: Can cause false negatives in glucose tests
(dipstick method).
- Antibiotics
(e.g., Rifampin): May colour urine red or orange, affecting visual analysis.
Tags:
Pharmacology (DMLT)